Introduction to Leonate 60mg Injection

The Leonate 60mg Injection contains the drug Artesunate, mainly intended for the eradication of malaria, specifically in critical conditions. The drug is part of the artemisinin category and is featured on the World Health Organization's List of Essential Medicines.

Functioning as a prodrug, it promptly converts into its active version, the dihydroartemisinin (DHA). The conversion triggers reactive oxygen species generation, leading to oxidative stress and damage to malaria-causing proteins. Besides, it blocks the essential Plasmodium falciparum exported protein 1 (EXP1), thereby lowering parasite glutathione levels.

While the tolerance level is generally high , common adverse effects might comprise slow pulse rate, allergic responses, vertigo, and diminished white blood cell levels. In extreme conditions, cases of kidney failure needing dialysis, hemoglobinuria (appearance of hemoglobin in urine), and jaundice have been documented.

It is believed to be safe during gestation, especially during the latter two trimesters, yet caution is recommended during the initial trimester. It is largely secure for pediatric use, with dosage adjustments necessary for those below 20 kg. In particular, it should be avoided in newborns when mixed with sulfadoxine/pyrimethamine because of potential impacts on bilirubin.

In case of a skipped dose, it is vital to seek advice from a healthcare expert to recommend the best course of action. The time and severity of the missed dosage will be taken into account for determining the proper response.

Leonate 60mg Injection

How Leonate 60mg Injection Works?

Artesunate morphs into a potent shape, DHA, behaving like a champion. It interacts with heme, generating free radicals that interfere with the development of malaria parasites in red blood cells. This tactical assault debilitates the parasites at each phase, obstructing their expansion and ultimately overpowering them in the fight against malaria. It's akin to a champion dismantling the adversary's protections and guaranteeing they can't reproduce, safeguarding the body from malaria.

How To Use Leonate 60mg Injection

  • Your physician or healthcare provider will supply this drug; please refrain from self-administration.
  • Refrain from consuming it individually; wait for instructions from your physician or healthcare provider.
  • Have faith in your medical professional to deliver the drug; do not try self-administration.

Special Precautions About Leonate 60mg Injection

  • Artesunate is primarily used for the treatment of severe malaria, especially caused by Plasmodium falciparum. It is not typically used for uncomplicated malaria. The diagnosis of severe malaria must be confirmed before initiating treatment with Artesunate.
  • Regular monitoring of liver function is recommended during Artesunate treatment, especially in patients with preexisting liver conditions. Elevated liver enzymes may occur, and dose adjustments or discontinuation may be necessary.

Benefits Of Leonate 60mg Injection

  • Rapid and effective malaria treatment.
  • Improves recovery from malaria.
  • Demonstrates high antimalarial potency.

Side Effects Of Leonate 60mg Injection

  • Headache
  • Dizziness
  • Vomiting
  • Abdominal pain
  • Cough
  • Decreased white blood cell count
  • Taste change
  • Fever

What If I Missed A Dose Of Leonate 60mg Injection

Your doctor or nurse keeps a close eye on when you need it. It''s rare to miss a dose, but if you suspect it, let them know. They''re there to ensure you receive the right treatment at the right time.

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Safety Advice For Leonate 60mg Injection

check for risk indication explain below.

  • High risk
  • Moderate risk.
  • Safe

Alcohol

The combination of alcohol and Leonate 60mg Injection's safety is unknown. Consult with your doctor for advice specifically tailored to you regarding alcohol consumption while on this medication.

Pregnancy

Based on animal studies, Leonate 60mg Injection might be unsafe for use during pregnancy as it may pose potential harm to the unborn child. Seek advice from your doctor to weigh the risks and benefits before using this medicine.

Breast feeding

Leonate 60mg Injection is considered safe during breastfeeding period. Sparse human data suggests negligible risk to the infant. Follow your doctor's instructions and advice for a secure breastfeeding experience.

Kidney

Scarce information exists regarding the use of Leonate 60mg Injection in patients suffering from kidney disease. Seek individualized advice from your doctor and potential adjustments based on your kidney condition.

Liver

There is little information on the use of Leonate 60mg Injection in patients with liver disease. Consult your doctor for tailored advice and possible adjustments based on your liver's health.

Alcohol

The combination of alcohol and Leonate 60mg Injection's safety is unknown. Consult with your doctor for advice specifically tailored to you regarding alcohol consumption while on this medication.

Pregnancy

Based on animal studies, Leonate 60mg Injection might be unsafe for use during pregnancy as it may pose potential harm to the unborn child. Seek advice from your doctor to weigh the risks and benefits before using this medicine.

Breast feeding

Leonate 60mg Injection is considered safe during breastfeeding period. Sparse human data suggests negligible risk to the infant. Follow your doctor's instructions and advice for a secure breastfeeding experience.

Kidney

Scarce information exists regarding the use of Leonate 60mg Injection in patients suffering from kidney disease. Seek individualized advice from your doctor and potential adjustments based on your kidney condition.

Liver

There is little information on the use of Leonate 60mg Injection in patients with liver disease. Consult your doctor for tailored advice and possible adjustments based on your liver's health.

Drug Interaction

  • Consult a healthcare provider for an accurate interpretation of interactions with Artesunate; seek immediate help if experiencing adverse effects.,Note that the absence of interaction does not guarantee any interactions.,Exercise caution with drugs like Acetophenazine, Alimemazine, and Artemether, which may increase QTc prolongation.,Ambroxol can elevate the risk of methemoglobinemia when combined with Artesunate.,Stay vigilant with Articaine, as its combination with Artesunate may also heighten the risk of methemoglobinemia.

DRUG-FOOD INTERACTION

  • No interactions were identified between Artesunate and food; consult a healthcare provider for accurate information and potential drug-related concerns.,Consult your healthcare provider for more information.

Disease Explanation

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Malaria is a disease caused by a parasite that infects some types of mosquitoes. When an infected mosquito bites a person, it can transmit the parasite to their blood. Malaria can cause fever, headache, chills, and sometimes severe complications or death. Malaria can be prevented by avoiding mosquito bites and taking medicines.