In conclusion glimepiride is safe, effective and has clearly-definable pharmacokinetics in diabetic patients with renal impairment. The increased plasma elimination of glimepiride with decreasing kidney function is explainable on the basis of altered protein binding with an increase in unbound drug.

Novartis Galvus (vildagliptin) is a member of a class of oral antidiabetic agents known as dipeptidyl peptidase IV inhibitors (DPP-IV) inhibitors or incretin enhancers.

Voglibose (INN and USAN, trade name Voglib, marketed by Mascot Health Series) is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. Voglibose delays the absorption of glucose thereby reducing the risk of macrovascular complications.

According to the University of Michigan, you should avoid eating high-fiber foods after taking metformin. This is because fiber can bind to drugs and lower their concentration. Metformin levels decrease when taken with large amounts of fiber (greater than 30 grams per day).

Nausea, vomiting, stomach upset, diarrhea, weakness, or a metallic taste in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If stomach symptoms return later (after taking the same dose for several days or weeks), tell your doctor right away.

Metformin works by reducing the amount of sugar your liver releases into your blood. It also makes your body respond better to insulin. Insulin is the hormone that controls the level of sugar in your blood. Its best to take metformin with a meal to reduce the side effects.

Metformin is still the safest and most effective type 2 diabetes medication, said Bolen. She is an assistant professor of medicine at Case Western Reserve Universitys Center for Health Care Research and Policy, in Cleveland.

Can long-term metformin use cause kidney damage? Metformin does not cause kidney damage. The kidneys process and clear the drug out of your system via urine. If your kidneys are not functioning properly, metformin can build up in your system and cause a condition called lactic acidosis.

The usual adult dosage is 0.2 mg of voglibose administered orally three times daily immediately before each meal. Voglibose 0.2 mg or OD Tablets 0.2 mg will be administered orally three times daily immediately before each meal.