Bisonate is safe if used as a medication and as prescribed by the doctor. However, excess of Bisonate can disturb the fine balance of electrolytes (like sodium, potassium, carbonate, etc.) that is needed by the body to function properly. As a result, it can cause unwanted side effects. Therefore, to avoid such disturbances, Bisonate is usually prescribed for maximum of 2 weeks when taken orally as taking it in excess can cause transient alkalosis, which can be harmful.

Excess of Bisonate causes alkalosis (excessive blood alkalinity) which can be observed as mood changes, tiredness, slow breathing, muscle weakness and irregular heartbeat. Muscle hypertonicity, twitching and tetany may develop, especially in patients with low levels of calcium in blood.

Bisonate is an antacid used to relieve acid indigestion, heartburn, and gas. When taken orally, it neutralizes the acid present in the stomach by producing carbon dioxide which results in reduction of irritation in stomach and intestine.