PX 20mg Injection
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Create ABHAIntroduction to PX 20mg Injection
It is a pain-relieving medicine that helps in treating moderate to severe pain.
- This medicine relieves pain and swelling in conditions related to muscles and joints.
- It is generally injected when oral administration is not suitable.
How PX 20mg Injection works
It is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that are responsible for inflammation (pain and swelling).
How To Use PX 20mg Injection
- Your doctor or nurse will give you this medicine. Kindly do not self administer.
- You should keep receiving the medicine until the doctor says it is okay to stop using the medicine.
- Strictly follow the dose and duration suggested by a healthcare professional.
Special Precautions for PX 20mg Injection
- If side effects persist or get worse, you should let your doctor know.
- Before using it, you should let your doctor know if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease.
- Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.
- Pregnant and breastfeeding mothers must consult with their doctors before using the medicine.
Benefits Of PX 20mg Injection
- Helps to relieve pain in conditions like osteoarthritis and rheumatoid arthritis.
Uses of PX 20mg Injection
- Pain relief
Side Effects Of PX 20mg Injection
- Vomiting
- Stomach pain
- Nausea
- Indigestion
- Diarrhea
- Injection site reactions (pain, swelling, redness)
What If I Missed A Dose Of PX 20mg Injection
- Don't skip any drug of the dose. If forgotten, take it once remembered.
- If the next dose time is near, skip the missed one.
- Avoid doubling to compensate. Follow this routine for safe and effective usage.
- For guidance on managing missed doses, consult your healthcare provider, ensuring proper adherence to the prescribed regimen.
Health And Lifestyle
Avoid overuse of alcohol. Maintain Balance diet and stay hydrated. If you are regularly exercising than incorporate light exercise to manage pain and Inflammation better.
Drug Interaction
- Anticoagulants (e.g., Warfarin)
- Antihypertensives (e.g., ACE inhibitors)
Drug Food Interaction
- Alcohol
- Grapefruit Juice
Disease Explanation
Pain- Pain signals the nervous system that something may be wrong, and can be sharp or dull, coming or going. It can be experienced in one area or all over. There are two types of pain: acute and chronic. Acute pain, sudden and often treated, can go away, while chronic pain can last for years and cause severe problems.
Safety Advice for PX 20mg Injection
- High risk
- Moderate risk
- Safe
Caution is advised when consuming alcohol with this drug. Please consult your doctor.
It is unsafe to use during pregnancy as it may pose risk to the developing baby. Please consult your doctor.
It is considered to be safe to use during breastfeeding. The drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
It may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
It should be used cautiously in patients with severe kidney disease. Dose adjustment of the drug may be needed. Please consult your doctor.
The drug should be used with caution in patients with liver disease. Dose adjustment of drug may be needed. Please consult your doctor.
FAQ's on PX 20mg Injection
Can PX be used with lithium?
No. PX should not be used with lithium. PX leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.
Can I use PX for a migraine?
PX is not approved for the treatment of migraine. Research studies have shown that PX is effective in significantly decreasing the pain associated with migraine without aura.
Is PX a sulfa drug?
PX is a sulphur containing compound. PX can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.
Is PX affective in gout management?
Yes. PX can be given for the treatment of acute gout. Research studies have shown PX to be highly effective in the treatment of acute gout.
What is the difference between PX and meloxicam?
Both PX and meloxicam are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, acute gastric side effects are lesser with meloxicam as compared to PX.
How long does PX work?
PX is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.
What is the difference between PX and tramadol?
PX is a COX (cyclooxygenase -an enzyme responsible for inflammation and pain) whereas Tramadol is a narcotic-like painkiller. Tramadol is a habit forming medicine.
Can PX be used in the treatment of chikungunya?
Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking PX or any painkiller in the case of any fever with joint pain. Consult your doctor before starting PX.
Can PX be used along with dexamethasone?
No. PX should not be used with dexamethasone. They both increase each others toxicity. There is an increased risk of GI ulceration.
Can PX be used with Lisinopril?
No. PX should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting PX.
Can PX be used with Tizanidine?
Yes, PX can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.
Can PX lead to difficulty in conception?
Yes. PX can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.
Why is beta cyclodextrin added to PX?
Yes. PX can be combined with beta-cyclodextrin. Research has shown that combining PX with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.
Can PX be used in hypertension?
No. PX is not a medication to control hypertension. It is important to note that PX decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting PX.
Can PX be used with calcium channel blocker?
Yes. PX can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)
Is PX a blood thinner?
No. PX is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.
Can PX be used in the treatment of allergy?
No. PX is not a drug to treat allergy. It is a pain killer.
Is PX effective in back pain management?
Yes. It can be given for decreasing the back pain. However, you should consult your doctor for the exact cause of your back pain and then start the treatment. Do not self-medicate yourself with PX as the cause of back pain can be different for different person.
Can I use PX if I have asthma?
Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.
Is PX a muscle relaxant?
No. PX is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.
Can PX lead to skin reactions?
Yes. PX is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.
Can I use PX if I am pregnant?
No. PX should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.
Can PX be used along with paracetamol?
Yes. Paracetamol can be used with PX as no serious side effects are known. Inform your doctor before starting any of the medication.
Can I use PX if I have peptic ulcer disease?
No. PX is contraindicated in cases of active peptic ulcer disease. PX is known to cause gastric ulceration and bleeding.
What is the difference between PX and ketoprofen?
Both PX and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to PX. Ketoprofen gel also showed excellent tolerability.
What is the difference between PX and diclofenac?
Both PX and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to PX.
Can PX be used with methocarbamol?
Yes. Methocarbamol can be used with PX as no serious side effects are known. Inform your doctor before starting any of the medication.
Can you donate blood when on the medication with PX?
Yes. You can donate blood when on PX. Do inform your doctor before donating blood.
Are there any alternatives of PX?
Yes. There are alternatives to PX. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.
Can PX be used to treat menstrual cramp?
PX is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.
What are the contraindications for PX?
Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.
Can PX be used along with Losartan?
No. PX should not be combined with Losartan. It is important to note that PX decreases the effectiveness of the antihypertensive medication like losartan when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting PX.
Are PX and aspirin same?
No. PX and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.
Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)/ PX?
Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.
What are the serious side effects of PX?
GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.
What increases the chances of getting a gastric ulcer when I am already taking PX?
The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.
What is the difference between PX and naproxen?
Both PX and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to PX.
Can I use PX if I have a deranged renal function?
No. PX should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.
Is PX a narcotic?
No. PX is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.
Can PX be used with warfarin?
No. PX should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.
Can I use PX if I am a diabetic?
PX in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal PX so taking piroxicam can lead to increased risk of renal failure by many folds.
Can you get high by using PX?
No. PX is not known to cause high. It is a non-narcotic painkiller.
What is the difference between PX and nimesulide?
Both PX and nimesulide are pain killers. However, PX is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.
Can PX be used with diuretics?
No. PX should not be used with diuretics. PX reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
Is PX a NSAID?
Yes. PX is a non-steroidal anti-inflammatory drug (NSAID).
Written By
Rakshita Garg
M.Pharma
Content Updated on
Saturday, 27 July, 2024
